Butyllithium reaction is a kind of reaction that needs to be carried out under super low temperature conditions. The reaction process will generate a lot of heat and is a kind of dangerous reaction process. The traditional process is dripping, which is inefficient and dangerous.
Using the continuous microchannel flowreactor , the reaction time has been shortened from 4h to 0.8s now, and the production process does not require nitrogen protection, which improves the efficiency, and reduces the solvent consumption nearly 20%.
